Enantioselective Synthesis-3

Enantioselective alkylation
Alkylation of aldehydes and ketones

Alkylation of lithiated dimethyl hydrazones forms the basis of asymmetric alkylation of aldehydes and ketones. The following steps are involved.

alkylation of ketones
alkylation of ketones
Alkylation of α-amino acids

 Alkylation of α-amino acids without loss of chirality, or using chiral auxiliary reagents have been effected as follows.

alkylation of amino acid
alkylation of amino acid
Intra-molecular aldol condensation
intramolecular aldol
Enatioselectivity: Michael addition- Phase transfer catalysts-Reduction with chiral hydride donors
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